Ethyl Acetate → HCID 54500731, compound

HRID 974296Notes

Reaction equation

HRID 974296 reaction equation
[CH3:1][C:2]1[CH:11]=[CH:10][CH:9]=[CH:8][C:3]=1[CH:4]=[CH:5][CH2:6]Cl.[NH2:12][C:13]1[S:14][C:15]2[CH2:16][CH2:17][NH:18][CH2:19][CH2:20][C:21]=2[N:22]=1.C(OCC)(=O)C>C(Cl)(Cl)Cl>[NH2:12][C:13]1[S:14][C:15]2[CH2:16][CH2:17][N:18]([CH2:6][CH:5]=[CH:4][C:3]3[CH:8]=[CH:9][CH:10]=[CH:11][C:2]=3[CH3:1])[CH2:19][CH2:20][C:21]=2[N:22]=1

Participants

5

Reactant 3

HCID 8857Ethyl AcetateHCID 199857852-Amino-4,5,6,7,8-pentahydrothiazolo[5,4-d]azepineHCID 53741517HCID 53741517, compound

Product 1

HCID 54500731HCID 54500731, compoundYield 52%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

Prepared from 2-methyl-cinnamyl chloride and 2 equivalents of 2-amino-4,5,7,8-tetrahydro-6H-thiazolo[5,4-d]azepine in chloroform. Yield: 52% of theory, Melting point: 112°-115° C. (ethyl acetate).

Sources & evidence

ORD record
ord-fc7e5938a8054ce7ab10d0076d229040
Source dataset
uspto-grants-1991_11
Patent number
US05068325

Reaction notes

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