3-(Pyridin-3-yl)acrylaldehyde → HCID 54319254, compound

HRID 974324Notes

Reaction equation

HRID 974324 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH:7]=[CH:8][CH:9]=O)[CH:2]=1.[NH2:11][C:12]1[S:13][C:14]2[CH2:15][CH2:16][NH:17][CH2:18][CH2:19][C:20]=2[N:21]=1.C([BH3-])#N.[Na+]>>[NH2:11][C:12]1[S:13][C:14]2[CH2:15][CH2:16][N:17]([CH2:9][CH:8]=[CH:7][C:3]3[CH:2]=[N:1][CH:6]=[CH:5][CH:4]=3)[CH2:18][CH2:19][C:20]=2[N:21]=1

Participants

4

Reactant 3

HCID 3094653-(Pyridin-3-yl)acrylaldehydeHCID 5003444Sodium cyanoborohydrideHCID 199857852-Amino-4,5,6,7,8-pentahydrothiazolo[5,4-d]azepine

Product 1

HCID 54319254HCID 54319254, compoundYield 40%

Procedure

Prepared from 3-(3-pyridyl)acrolein and 2-amino-4,5,7,8-tetrahydro-6H-thiazolo[5,4-d]azepine by reductive amination with sodium cyanoborohydride. Yield: 40% of theory, Melting point: 162°-165° C.

Sources & evidence

ORD record
ord-e03e85ecb75b4ed29b4662d9723dbb12
Source dataset
uspto-grants-1991_11
Patent number
US05068325

Reaction notes

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