Acetone → HCID 54328344, compound

HRID 974337Notes

Reaction equation

HRID 974337 reaction equation
[NH2:1][C:2]1[S:3][C:4]2[CH2:5][CH2:6][NH:7][CH2:8][CH2:9][C:10]=2[N:11]=1.C(=O)([O-])[O-].[K+].[K+].[C:18]([C:20]1[CH:29]=[CH:28][CH:27]=[CH:26][C:21]=1[CH:22]=[CH:23][CH2:24]Br)#[N:19].CC(C)=O>CN(C)C=O>[NH2:1][C:2]1[S:3][C:4]2[CH2:5][CH2:6][N:7]([CH2:24][CH:23]=[CH:22][C:21]3[CH:26]=[CH:27][CH:28]=[CH:29][C:20]=3[C:18]#[N:19])[CH2:8][CH2:9][C:10]=2[N:11]=1

Participants

6

Reactant 4

HCID 180AcetoneHCID 11430Potassium CarbonateHCID 199857852-Amino-4,5,6,7,8-pentahydrothiazolo[5,4-d]azepineHCID 53866139HCID 53866139, compound

Product 1

HCID 54328344HCID 54328344, compoundYield 31%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Prepared analogously to Example 1 from 2-amino-4,5,7,8-tetrahydro-6H-thiazolo[5,4-d]azepine, potassium carbonate and 2-cyano-cinnamyl bromide (melting point: 69°-71° C.) in anhydrous dimethylformamide for 15 hours at 20° C. Yield: 31% of theory, Melting point: 140°-144° C. (acetone).

Sources & evidence

ORD record
ord-b07d60801dc34948879658ba48b6dc29
Source dataset
uspto-grants-1991_11
Patent number
US05068325

Reaction notes

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