Diethyl Ether → HCID 53961605, compound

HRID 974338Notes

Reaction equation

HRID 974338 reaction equation
[NH2:1][C:2]1[S:3][C:4]2[CH2:5][CH2:6][NH:7][CH2:8][CH2:9][C:10]=2[N:11]=1.C(=O)([O-])[O-].[K+].[K+].[C:18]([C:20]1[CH:21]=[C:22]([CH:27]=[CH:28][CH:29]=1)[CH:23]=[CH:24][CH2:25]Br)#[N:19].CCOCC>CN(C)C=O>[NH2:1][C:2]1[S:3][C:4]2[CH2:5][CH2:6][N:7]([CH2:25][CH:24]=[CH:23][C:22]3[CH:27]=[CH:28][CH:29]=[C:20]([C:18]#[N:19])[CH:21]=3)[CH2:8][CH2:9][C:10]=2[N:11]=1

Participants

6

Reactant 4

HCID 3283Diethyl EtherHCID 11430Potassium CarbonateHCID 199857852-Amino-4,5,6,7,8-pentahydrothiazolo[5,4-d]azepineHCID 54113347HCID 54113347, compound

Product 1

HCID 53961605HCID 53961605, compoundYield 48%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Prepared analogously to Example 1 from 2-amino-4,5,7,8-tetrahydro-6H-thiazolo[5,4-d]azepine, potassium carbonate and 3-cyano-cinnamyl bromide (melting point: 52°-55° C.) in anhydrous dimethylformamide for 2 hours at 20° C. Yield: 48% of theory, Melting point: 136°-140° C. (ether).

Sources & evidence

ORD record
ord-fc81876d024e49eeae851652b8fd4327
Source dataset
uspto-grants-1991_11
Patent number
US05068325

Reaction notes

Loading…