Potassium Carbonate → HCID 54346962, compound

HRID 974400Notes

Reaction equation

HRID 974400 reaction equation
Cl[CH2:2][C:3]([CH3:17])([CH3:16])[C:4]([NH:6][CH2:7][C:8]1[CH:13]=[CH:12][C:11]([F:14])=[CH:10][C:9]=1[F:15])=[O:5].C(=O)([O-])[O-].[K+].[K+]>C(C(C)=O)C>[CH3:2][C:3]1([CH3:17])[CH2:16][N:6]([CH2:7][C:8]2[CH:13]=[CH:12][C:11]([F:14])=[CH:10][C:9]=2[F:15])[C:4]1=[O:5]

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 2779689N1-(2,4-Difluorobenzyl)-3-Chloro-2,2-Dimethylpropanamide

Product 1

HCID 54346962HCID 54346962, compound

Reagents, catalysts & solvents 1

HCID 6569Methyl Ethyl KetoneSolvent

Conditions

Temperature
75 °C

Procedure

49.7 g (0.19 mol) of 3-chloro-2,2-dimethyl-N-[(2,4-difluorophenyl)methyl]propanamide and 78.8 g (0.57 mol) of potassium carbonate are suspended in 200 ml of methyl ethyl ketone, and the suspension is warmed and stirred at 75° C. for 24 hours. When the reaction is complete (GC check), the mixture is filtered, and the filtrate is evaporated on a vacuum rotary evaporator. 40.9 g (95% of theory) of a yellow oil are obtained.

Workup

  1. temperaturethe suspension is warmed
  2. filtrationthe mixture is filtered
  3. customthe filtrate is evaporated on a vacuum rotary evaporator
  4. custom40.9 g (95% of theory) of a yellow oil are obtained

Sources & evidence

ORD record
ord-3a4addd6971d49d5955b43b04fb7c208
Source dataset
uspto-grants-1991_11
Patent number
US05068371

Reaction notes

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