Acetic Acid → (5-Bromo-2-fluorophenyl)boronic acid

Temperature

-78 °C

A solution of 2,4-dibromofluorobenzene (12.7 g, containing 30% 3,4-dibromofluorobenzene) in dry tetrahydrofuran (THF) (10 ml) is added over 5 min to a stirred suspension of magnesium turnings (1.15 g) in dry THF (50 ml) under an atmosphere of nitrogen and cooled in a water bath. After 1 hour, when all the magnesium has reacted, this reagent is added over 20 min to a stirred solution of trimethoxyborane (7 ml) in dry diethyl ether (80 ml) under an atmosphere of nitrogen and cooled at -78° C. The mixture is stirred at -78° C. for a further 15 min. and glacial acetic acid (6 ml) added followed by water (50 ml). The mixture is warmed to room temperature, extracted with diethyl ether (x3), washed with water, dried and the solvent evaporated under reduced pressure. The residue is stirred with carbon tetrachloride (30 ml) and then cooled at 0° C. The crystals of dihydroxy-(5-bromo-2-fluorophenyl)-borane are filtered off and washed with a little carbon tetrachloride. Yield 2.8 g m.pt. 173°-174° C.

1. temperaturecooled in a water bath
2. temperatureThe mixture is warmed to room temperature
3. extractionextracted with diethyl ether (x3)
4. washwashed with water
5. customdried
6. customthe solvent evaporated under reduced pressure
7. stirringThe residue is stirred with carbon tetrachloride (30 ml)
8. temperaturecooled at 0° C
9. filtrationThe crystals of dihydroxy-(5-bromo-2-fluorophenyl)-borane are filtered off
10. washwashed with a little carbon tetrachloride

ORD record

ord-d0b36f5592834850b6e069f49a1c7930

Source dataset

uspto-grants-1991_11

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05068403