Triethylamine → HCID 15053433, compound

HRID 974594Notes

Reaction equation

HRID 974594 reaction equation
C(O)(=O)C(O)=O.[F:7][C:8]1[CH:9]=[C:10]([CH:16]=[CH:17][CH:18]=1)[O:11][CH:12]1[CH2:15][NH:14][CH2:13]1.[CH3:19][N:20]=[C:21]=[O:22].C(N(CC)CC)C>O1CCCC1.O>[F:7][C:8]1[CH:9]=[C:10]([CH:16]=[CH:17][CH:18]=1)[O:11][CH:12]1[CH2:15][N:14]([C:21]([NH:20][CH3:19])=[O:22])[CH2:13]1

Participants

6

Reactant 3

HCID 8471TriethylamineHCID 12228Methyl IsocyanateHCID 197995893-(3-Fluorophenoxy)azetidine oxalate

Product 1

HCID 15053433HCID 15053433, compoundYield 66.9%

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

A stirred mixture of 5.4 g (0.02 mole) of 3-(3-fluorophenoxy)-azetidine oxalate and 1.7 g (0.022 mole) of methyl isocyanate in 20 ml of tetrahydrofuran was treated with 5 ml of triethylamine then stirring was continued for 3 hr. The reaction was diluted with water and the fine crystalline precipitate obtained was collected by filtration and dried at 60° C. under vacuum to yield 3 g (66.9%) of product, m.p. 155°-156° C.

Workup

  1. customthe fine crystalline precipitate obtained
  2. filtrationwas collected by filtration
  3. customdried at 60° C. under vacuum

Sources & evidence

ORD record
ord-626bcd61e5654808af8efaebe0934948
Source dataset
uspto-grants-1991_11
Patent number
US05068231

Reaction notes

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