Ammonium Hydroxide → HCID 15053448, compound

HRID 974614Notes

Reaction equation

HRID 974614 reaction equation
[Cl:1][C:2]1[CH:15]=[CH:14][C:5]([O:6][CH:7]2[CH2:10][N:9]([C:11](Cl)=[O:12])[CH2:8]2)=[CH:4][CH:3]=1.[OH-].[NH4+:17]>O1CCCC1.O>[Cl:1][C:2]1[CH:15]=[CH:14][C:5]([O:6][CH:7]2[CH2:10][N:9]([C:11]([NH2:17])=[O:12])[CH2:8]2)=[CH:4][CH:3]=1

Participants

5

Reactant 2

HCID 14923Ammonium HydroxideHCID 15042229HCID 15042229, compound

Product 1

HCID 15053448HCID 15053448, compoundYield 52.9%

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

A solution of 5 g (0.02 mole) of 3-(4-chlorophenoxy)-1-azetidinecarbonyl chloride in 20 ml of tetrahydrofuran was stirred while 4 ml (0.06 mole) of 57% ammonium hydroxide was added all at once. After stirring for 18 hr, the reaction mixture was diluted with 200 ml of water and the solid which separated was collected by filtration, 10.5 g. Recrystallization from isopropanol yielded 2.4 g (52.9%) of gray crystalline powder, m.p. 187°-188° C.

Workup

  1. additionwas added all at once
  2. customthe solid which separated
  3. filtrationwas collected by filtration, 10.5 g
  4. customRecrystallization from isopropanol

Sources & evidence

ORD record
ord-c6eb296d65eb4e44aed771720a40f514
Source dataset
uspto-grants-1991_11
Patent number
US05068231

Reaction notes

Loading…