Hydrogen Peroxide → HCID 23450679, compound

HRID 974832Notes

Reaction equation

HRID 974832 reaction equation
[C:1]([C:4]1[C:5]([Cl:17])=[C:6]2[C:11](=[C:12]([Cl:14])[CH:13]=1)S[CH2:9][CH2:8][C:7]2([CH3:16])[CH3:15])(=[O:3])[CH3:2].OO.[S:20]([O-:23])(O)=[O:21].[Na+]>C(O)(=O)C>[C:1]([C:4]1[C:5]([Cl:17])=[C:6]2[C:11](=[C:12]([Cl:14])[CH:13]=1)[S:20](=[O:23])(=[O:21])[CH2:9][CH2:8][C:7]2([CH3:16])[CH3:15])(=[O:3])[CH3:2]

Participants

5

Reactant 3

HCID 784Hydrogen PeroxideHCID 23450706HCID 23450706, compoundHCID 23665763Sodium Bisulfite

Product 1

HCID 23450679HCID 23450679, compoundYield 71%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
80 °C

Procedure

1 ml of acetic acid was added to 1.22 g (4.22 mmol) of 6-acetyl-5,8-dichloro-4,4-dimethylthiochroman, 1.43 g (12.66mmol) of a 30% hydrogen peroxide aqueous solution was further added, and the mixture was heated at 80° C. for 2 hours. To the reaction mixture was added 10 ml of a 2% sodium hydrogensulfite, and a precipitated solid was recovered by filtration to give 0.96 g (yield 71%) of 6-acetyl-5,8-dichloro-4,4-dimethylthiochroman-1,1-dioxide.

Workup

  1. additionwas further added
  2. filtrationa precipitated solid was recovered by filtration

Sources & evidence

ORD record
ord-a299c5cd1d694e969bf05888bafe1af0
Source dataset
uspto-grants-1997_03
Patent number
US05607898

Reaction notes

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