Hydrogen Peroxide → HCID 23450713, compound

HRID 974839Notes

Reaction equation

HRID 974839 reaction equation
[CH3:1][CH:2]1[C:11]2[C:6](=[C:7]([CH3:16])[CH:8]=[C:9]([C:13]([OH:15])=[O:14])[C:10]=2[CH3:12])S[CH2:4][CH2:3]1.OO.[S:19]([O-:22])(O)=[O:20].[Na+]>C(O)(=O)C>[CH3:1][CH:2]1[C:11]2[C:6](=[C:7]([CH3:16])[CH:8]=[C:9]([C:13]([OH:15])=[O:14])[C:10]=2[CH3:12])[S:19](=[O:22])(=[O:20])[CH2:4][CH2:3]1

Participants

5

Reactant 3

HCID 784Hydrogen PeroxideHCID 23450665HCID 23450665, compoundHCID 23665763Sodium Bisulfite

Product 1

HCID 23450713HCID 23450713, compoundYield 98%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A 30-ml eggplant type flask was charged with 0.75 g (3.2 mmol) of the 4,5,8-trimethylthiochroman-6-carboxylic acid, 1.1 g (9.5 mmol) of 30% hydrogen peroxide and 1 ml of acetic acid, and the mixture was allowed to react at 100° C. for 2 hours. The reaction mixture was poured into a sodium hydrogensulfite aqueous solution and extracted with ethyl acetate. The extract was washed with a saturated sodium chloride aqueous solution and dried over sodium sulfate, and the solvent was distilled off to give 0.76 g (yield 98%) of 4,5,8-trimethylthiochroman-6-carboxylic acid-1,1,dioxide.

Workup

  1. customto react at 100° C. for 2 hours
  2. extractionextracted with ethyl acetate
  3. washThe extract was washed with a saturated sodium chloride aqueous solution
  4. dry with materialdried over sodium sulfate
  5. distillationthe solvent was distilled off

Sources & evidence

ORD record
ord-6a8de14640d9469d83a7343cca2c3feb
Source dataset
uspto-grants-1997_03
Patent number
US05607898

Reaction notes

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