Morpholine → HCID 178473649, compound

HRID 974883Notes

Reaction equation

HRID 974883 reaction equation
N1CCOCC1.C(OC([N:13]1[CH2:19][CH2:18][C:17]2[S:20][C:21]([CH:23]3[CH2:28][CH2:27][N:26]([C:29]([NH:31][C@H:32]4[CH2:37][CH2:36][C@H:35]([C:38]([O:40][CH:41]([O:43][C:44]([O:46][CH2:47][CH3:48])=[O:45])[CH3:42])=[O:39])[CH2:34][CH2:33]4)=[O:30])[CH2:25][CH2:24]3)=[N:22][C:16]=2[CH2:15][CH2:14]1)=O)C=C>O1CCCC1.C1C=CC(P(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.C1C=CC(P(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.C1C=CC(P(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.C1C=CC(P(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.[Pd]>[CH2:47]([O:46][C:44]([O:43][CH:41]([O:40][C:38]([C@H:35]1[CH2:34][CH2:33][C@H:32]([NH:31][C:29]([N:26]2[CH2:25][CH2:24][CH:23]([C:21]3[S:20][C:17]4[CH2:18][CH2:19][NH:13][CH2:14][CH2:15][C:16]=4[N:22]=3)[CH2:28][CH2:27]2)=[O:30])[CH2:37][CH2:36]1)=[O:39])[CH3:42])=[O:45])[CH3:48]

Participants

5

Reactant 2

HCID 8083MorpholineHCID 178459646HCID 178459646, compound

Product 1

HCID 178473649HCID 178473649, compound

Reagents, catalysts & solvents 2

HCID 11979704Tetrakis(triphenylphosphine)palladiumCatalystHCID 8028TetrahydrofuranSolvent

Procedure

Prepared by dropwise addition of one equivalent of morpholine to 6-allyloxycarbonyl-2-[1-[[trans-4-[[1-(ethoxycarbonyloxy)-ethyl]-oxycarbonyl]-cyclohexyl]aminocarbonyl]-piperid-4-yl]-4,5,7,8-tetrahydro-thiazolo[4,5-d]azepine and 0.1 equivalent of tetrakis-(triphenylphosphine)-palladium(O) in tetrahydrofuran followed by one hours' stirring at ambient temperature. The following compound is obtained analogously to Example 10:

Workup

  1. customThe following compound is obtained analogously to Example 10

Sources & evidence

ORD record
ord-6d2002f0ad4a40d3afdd2d13b477341d
Source dataset
uspto-grants-1997_03
Patent number
US05607944

Reaction notes

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