Potassium Carbonate → 1,2-Dimethyl-3-oxa-2,7-diazabicyclo[3.3.0]octane

HRID 974924Notes

Reaction equation

HRID 974924 reaction equation
C([N:4]1[CH2:11][C:10]2([CH3:12])[CH:6]([CH2:7][O:8][N:9]2[CH3:13])[CH2:5]1)(=O)C.[OH-].[Na+].C([O-])([O-])=O.[K+].[K+]>O>[CH3:12][C:10]12[CH2:11][NH:4][CH2:5][CH:6]1[CH2:7][O:8][N:9]2[CH3:13]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 14798Sodium HydroxideHCID 150700177-Acetyl-1,2-dimethyl-3-oxa-2,7-diazabicyclo[3.3.0]octane

Product 1

HCID 150700181,2-Dimethyl-3-oxa-2,7-diazabicyclo[3.3.0]octane

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

11.8 g (64 mmol) of 7-acetyl-1,2-dimethyl-3-oxa-2,7-diazabicyclo[3.3.0]octane are heated under reflux with 12 g of NaOH in 36 ml of water overnight. The mixture is saturated with K2CO3 and extracted several times with CHCl3, the extract is dried over K2CO3 and concentrated and the residue is distilled.

Workup

  1. extractionextracted several times with CHCl3
  2. dry with materialthe extract is dried over K2CO3
  3. concentrationconcentrated
  4. distillationthe residue is distilled

Sources & evidence

ORD record
ord-f11e245f3cb44d96a943fda29de7d7c4
Source dataset
uspto-grants-1997_03
Patent number
US05607942

Reaction notes

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