Methane → HCID 178430573, compound

HRID 974931Notes

Reaction equation

HRID 974931 reaction equation
[CH2:1]([N:8]=[C:9]([C:11]1[NH:12][CH:13]=[C:14]([CH3:20])[CH2:15][C:16]=1[C:17]([OH:19])=[O:18])[OH:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C>O1CCCC1.[Pd]>[CH2:1]([N:8]=[C:9]([CH:11]1[CH:16]([C:17]([OH:19])=[O:18])[CH2:15][CH:14]([CH3:20])[CH2:13][NH:12]1)[OH:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 2

HCID 297MethaneHCID 178430572HCID 178430572, compound

Product 1

HCID 178430573HCID 178430573, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8028TetrahydrofuranSolvent

Procedure

17.5 g (70 mmol) of 5-methyl-1,4-dihydropyridine-2,3-dicarboxylic acid N-benzylimide are hydrogenated in 150 ml of tetrahydrofuran at 70° C. and under 100 bar over palladium on active charcoal. Then the catalyst is filtered off and the filtrate is concentrated by evaporation. The solid oily residue (13.0 g) is used as a crude product in the next stage.

Workup

  1. filtrationThen the catalyst is filtered off
  2. concentrationthe filtrate is concentrated by evaporation

Sources & evidence

ORD record
ord-9b3ee59ac9cc446a9cc0fef679559428
Source dataset
uspto-grants-1997_03
Patent number
US05607942

Reaction notes

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