HCID 19969794, compound → HCID 19969814, compound

HRID 974933Notes

Reaction equation

HRID 974933 reaction equation
C([N:8]1[CH2:16][CH:15]2[CH:10]([CH2:11][CH:12]([CH3:17])[CH2:13][NH:14]2)[CH2:9]1)C1C=CC=CC=1>CO.[Pd].C>[CH3:17][CH:12]1[CH2:11][CH:10]2[CH:15]([CH2:16][NH:8][CH2:9]2)[NH:14][CH2:13]1

Participants

5

Reactant 1

HCID 19969794HCID 19969794, compound

Product 1

HCID 19969814HCID 19969814, compound

Reagents, catalysts & solvents 3

HCID 297MethaneSolventHCID 887MethanolSolventHCID 23938PalladiumSolvent

Procedure

8.0 g (35 mmol) of 8-benzyl-4-methyl-2,8-diazabicyclo[4.3.0]nonane are dissolved in 60 ml of methanol and hydrogenated over palladium on active charcoal at 100° C. and under 100 bar. Then the catalyst is filtered off, the filtrate is concentrated by evaporation and the residue is distilled.

Workup

  1. filtrationThen the catalyst is filtered off
  2. concentrationthe filtrate is concentrated by evaporation
  3. distillationthe residue is distilled

Sources & evidence

ORD record
ord-d823accfd9d042a894040d21ce51fcb5
Source dataset
uspto-grants-1997_03
Patent number
US05607942

Reaction notes

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