Hydrogen Bromide → HCID 19970307, compound

HRID 974982Notes

Reaction equation

HRID 974982 reaction equation
[CH2:1]([N:8]1[CH2:13][CH2:12][CH:11]([NH:14][C:15]([NH:17]C(C)(C)C)=[S:16])[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[BrH:22].C(OCC)C>C(O)(=O)C>[BrH:22].[CH2:1]([N:8]1[CH2:9][CH2:10][CH:11]([NH:14][C:15]([NH2:17])=[S:16])[CH2:12][CH2:13]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 260Hydrogen BromideHCID 3283Diethyl EtherHCID 2747423HCID 2747423, compound

Product 1

HCID 19970307HCID 19970307, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

17 g of N-(1-benzylpiperid-4-yl)-N'-tert-butylthiourea are added to 170 ml of 33% hydrobromic acid in acetic acid; the reaction mixture is stirred at room temperature for 4 hours, then it is poured over diethylether. The crystals obtained are filtered and they are thoroughly washed with diethylether in order to obtain white crystals which melt at 120° C.; yield: quantitative.

Workup

  1. customThe crystals obtained
  2. filtrationare filtered
  3. washthey are thoroughly washed with diethylether in order
  4. customto obtain white crystals which
  5. custommelt at 120° C.

Sources & evidence

ORD record
ord-fb3d83763f6a4bdfacfaaf656bc33681
Source dataset
uspto-grants-1997_03
Patent number
US05607952

Reaction notes

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