2-Methoxyethylamine → HCID 19970607, compound

HRID 975322Notes

Reaction equation

HRID 975322 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH:11][C:12]2[CH:13]=[CH:14][C:15]([C:18]([O:20]C)=O)=[N:16][CH:17]=2)(=[O:10])=[O:9])=[CH:4][CH:3]=1.[CH3:22][O:23][CH2:24][CH2:25][NH2:26]>>[CH3:22][O:23][CH2:24][CH2:25][NH:26][C:18]([C:15]1[CH:14]=[CH:13][C:12]([NH:11][S:8]([C:5]2[CH:4]=[CH:3][C:2]([F:1])=[CH:7][CH:6]=2)(=[O:9])=[O:10])=[CH:17][N:16]=1)=[O:20]

Participants

3

Reactant 2

HCID 80182-MethoxyethylamineHCID 19970451HCID 19970451, compound

Product 1

HCID 19970607HCID 19970607, compound

Procedure

0.5 g (1.61 mmol) of methyl 5-[(4-fluorophenylsulfonyl)amino]pyridine-2-carboxylate (compound from Example 4a) is stirred at 70° C. for 3 h in 5 ml of 2-methoxyethylamine. The mixture is concentrated, the residue is dissolved in water, the solution is acidified with conc. HCl, the solid is filtered off with suction and washed with water and 0.53 g of the title compound is obtained in the form of colorless crystals, M.p. 154° C.

Workup

  1. concentrationThe mixture is concentrated
  2. dissolutionthe residue is dissolved in water
  3. filtrationthe solid is filtered off with suction
  4. washwashed with water

Sources & evidence

ORD record
ord-63f29f76becf43b4814ada6b901ab2c9
Source dataset
uspto-grants-1997_03
Patent number
US05607954

Reaction notes

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