Hydrochloric Acid → HCID 19972019, compound

HRID 975491Notes

Reaction equation

HRID 975491 reaction equation
[ClH:1].C(OC([NH:9][CH:10]([P:18]([CH:23]([NH:31]C(OC(C)(C)C)=O)[CH2:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)(=[O:22])[O:19][CH2:20][CH3:21])[CH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)=O)(C)(C)C>CO>[ClH:1].[NH2:31][CH:23]([P:18]([CH:10]([NH2:9])[CH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)(=[O:22])[O:19][CH2:20][CH3:21])[CH2:24][C:25]1[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 11071548HCID 11071548, compound

Product 1

HCID 19972019HCID 19972019, compoundYield 97%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

An about 3N methanolic hydrochloric acid (10 ml) is added at room temperature with stirring to a solution of the bisalkylated phosphinic acid ester 10 (103 mg, 0.19 mol) in methanol (5 ml). After 3 hours, the reaction solution is concentrated under reduced pressure. The phosphinic acid ester hydrochloride 15 (69 mg, 97% of theory) is obtained.

Workup

  1. concentrationthe reaction solution is concentrated under reduced pressure

Sources & evidence

ORD record
ord-4e59333c25d64ca4a1ba6c10e068fcb2
Source dataset
uspto-grants-1997_03
Patent number
US05608098

Reaction notes

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