Hydrochloric Acid → HCID 22376950, compound

HRID 975492Notes

Reaction equation

HRID 975492 reaction equation
C(OC([NH:8][CH:9]([P:17]([CH:22]([NH:30]C(OC(C)(C)C)=O)[CH2:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)(=[O:21])[O:18]CC)[CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)=O)(C)(C)C.CO.C1(C)C=CC=CC=1.[ClH:47]>>[ClH:47].[NH2:8][CH:9]([P:17]([CH:22]([NH2:30])[CH2:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)(=[O:18])[OH:21])[CH2:10][C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 1140TolueneHCID 11071548HCID 11071548, compound

Product 1

HCID 22376950HCID 22376950, compoundYield 93%

Procedure

A solution of the bisalkylated phosphinic acid ester 10 (170 mg, 0.32 mmol) in 37% aqueous hydrochloric acid (20 ml) is heated to a temperature of about 100° C. for 6 hours. After concentration of the reaction solution under reduced pressure and repeated coevaporation with methanol and toluene, the phosphinic acid hydrochloride 16 (101 mg, 93% of theory) is obtained.

Sources & evidence

ORD record
ord-a11b849a8daa4d9a8334a1e97589d159
Source dataset
uspto-grants-1997_03
Patent number
US05608098

Reaction notes

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