Hydrochloric Acid → HCID 67713888, compound

HRID 975807Notes

Reaction equation

HRID 975807 reaction equation
C(OC([NH:8][C@@H:9]1[C:15](=[O:16])[N:14]([CH2:17][C:18]2[CH:23]=[CH:22][C:21]([CH:24]([CH3:26])[CH3:25])=[CH:20][CH:19]=2)[C:13]2[CH:27]=[CH:28][CH:29]=[CH:30][C:12]=2[O:11][CH2:10]1)=O)(C)(C)C.[ClH:31]>C(OCC)(=O)C>[ClH:31].[NH2:8][C@@H:9]1[C:15](=[O:16])[N:14]([CH2:17][C:18]2[CH:23]=[CH:22][C:21]([CH:24]([CH3:26])[CH3:25])=[CH:20][CH:19]=2)[C:13]2[CH:27]=[CH:28][CH:29]=[CH:30][C:12]=2[O:11][CH2:10]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 54070158HCID 54070158, compound

Product 1

HCID 67713888HCID 67713888, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

55 g of (S)-3-(tert-butoxycarbonylamino)-5-(p-isopropylbenzyl)-2,3,4,5-tetrahydro-1,5-benzoxazepin-4-one are dissolved in 180 ml of approximately 5 hydrochloric acid in ethyl acetate, foaming occurring. After stirring for two hours, the ochre-coloured suspension is concentrated and recrystallised from ether. The hygroscopic product has a m.p. of 215° C. (decomp.).

Workup

  1. concentrationthe ochre-coloured suspension is concentrated
  2. customrecrystallised from ether

Sources & evidence

ORD record
ord-45d3be595be64f1c8a27a59aad2a4283
Source dataset
uspto-grants-1997_03
Patent number
US05610153

Reaction notes

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