Benzyl Bromide → HCID 19968903, compound

HRID 976132Notes

Reaction equation

HRID 976132 reaction equation
C(=O)([O-])[O-].[K+].[K+].[CH2:7](Br)[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1.[N:15]1[C:20]2[CH2:21][CH2:22][CH2:23][C:19]=2[C:18]([NH:24][C:25]2[CH:30]=[CH:29][C:28]([C:31](=[O:39])[CH2:32][CH:33]3[CH2:38][CH2:37][NH:36][CH2:35][CH2:34]3)=[CH:27][CH:26]=2)=[N:17][CH:16]=1>CC(C)=O>[N:15]1[C:20]2[CH2:21][CH2:22][CH2:23][C:19]=2[C:18]([NH:24][C:25]2[CH:26]=[CH:27][C:28]([C:31](=[O:39])[CH2:32][CH:33]3[CH2:34][CH2:35][N:36]([CH2:7][C:8]4[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=4)[CH2:37][CH2:38]3)=[CH:29][CH:30]=2)=[N:17][CH:16]=1

Participants

5

Reactant 3

HCID 7498Benzyl BromideHCID 11430Potassium CarbonateHCID 19968957HCID 19968957, compound

Product 1

HCID 19968903HCID 19968903, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

50 ml of acetone, 1.14 g of potassium carbonate and 0.4 ml of benzyl bromide were added to 1.34 g of N-(5,6-dihydro-7H-cyclopenta[d]pyrimidin-4-yl)-4-[(piperidin-4-yl)acetyl]aniline, and the mixture was stirred at room temperature for 4 hours. After separating the solid by filtration and removing the solvent by distillation under reduced pressure, the obtained residue was applied to silica gel column chromatography to obtain 1.05 g of the title compound as yellowish white powder.

Workup

  1. customAfter separating the solid
  2. filtrationby filtration
  3. customremoving the solvent
  4. distillationby distillation under reduced pressure

Sources & evidence

ORD record
ord-6dc70e50fc8b4dbe9d0f221f9021615b
Source dataset
uspto-grants-1997_03
Patent number
US05610303

Reaction notes

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