Acetic Anhydride → HCID 54498287, compound

HRID 976138Notes

Reaction equation

[N:1]1[C:6]2[CH2:7][CH2:8][CH2:9][C:5]=2[C:4]([NH:10][C:11]2[CH:16]=[CH:15][C:14]([C:17](=[O:34])[CH2:18][CH2:19][CH:20]3[CH2:25][CH2:24][N:23]([CH2:26][C:27]4[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=4[NH2:33])[CH2:22][CH2:21]3)=[CH:13][CH:12]=2)=[N:3][CH:2]=1.[C:35](OC(=O)C)(=[O:37])[CH3:36]>CN(C)C1C=CN=CC=1.C(Cl)(Cl)Cl>[N:1]1[C:6]2[CH2:7][CH2:8][CH2:9][C:5]=2[C:4]([NH:10][C:11]2[CH:16]=[CH:15][C:14]([C:17](=[O:34])[CH2:18][CH2:19][CH:20]3[CH2:25][CH2:24][N:23]([CH2:26][C:27]4[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=4[NH:33][C:35](=[O:37])[CH3:36])[CH2:22][CH2:21]3)=[CH:13][CH:12]=2)=[N:3][CH:2]=1

Participants

Conditions

Temperature: 50 °C

Procedure

To 0.17 g of N-(5,6-dihydro-7H-cyclopenta[d]pyrimidin-4-yl)-4-(3-[1-(2-aminobenzyl)piperidin-4-yl]propanoyl)aniline were added 30 ml of chloroform, 1 ml of acetic anhydride and 0.38 g of 4-dimethylaminopyridine, and the mixture was stirred at 50° C. for 10 minutes. Then, the solvent was removed by distillation under reduced pressure and the obtained residue was applied to silica gel column chromatography to obtain 0.06 g of the title compound as white crystal.

Workup

customThen, the solvent was removed by distillation under reduced pressure

Sources & evidence

ORD record: ord-ef0cce73c1764c1083f987bb5da074a9
Source dataset: uspto-grants-1997_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05610303

Reaction notes

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