Trifluoroacetic acid → HCID 86750555, compound

HRID 976150Notes

Reaction equation

HRID 976150 reaction equation
C(O[NH:6][CH:7]1[CH:12]=[CH:11][C:10]([C:13](=[O:29])[CH2:14][C:15]2([OH:28])[CH2:20][CH2:19][N:18]([CH2:21][C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)[CH2:17][CH2:16]2)=[CH:9][C:8]1=C=O)(C)(C)C.[F:32][C:33]([F:38])([F:37])[C:34]([OH:36])=[O:35]>C(Cl)(Cl)Cl>[CH2:21]([N:18]1[CH2:17][CH2:16][C:15]([CH2:14][C:13]([C:10]2[CH:9]=[CH:8][C:7]([NH2:6])=[CH:12][CH:11]=2)=[O:29])([OH:28])[CH2:20][CH2:19]1)[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1.[F:32][C:33]([F:38])([F:37])[C:34]([O-:36])=[O:35]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86750556HCID 86750556, compound

Product 1

HCID 86750555HCID 86750555, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

30 ml of chloroform was added to 2.07 g of N-t-butoxy-carbonyl-4-[(1-benzyl-4-hydroxypiperidin-4-yl)acetyl]aniline, trifluoroacetic acid was added thereto three times in a total amount of 8 ml, and the mixture was stirred at room temperature. Thereafter, the solvent was removed by distillation under reduced pressure, and the obtained residue was applied to silica gel column chromatography to obtain 1.14 g of the title compound as reddish white powder.

Workup

  1. additionwas added
  2. customThereafter, the solvent was removed by distillation under reduced pressure

Sources & evidence

ORD record
ord-1a44d058383e4c079e38d619637c0667
Source dataset
uspto-grants-1997_03
Patent number
US05610303

Reaction notes

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