Hydrochloric Acid → HCID 19966772, compound

HRID 976225Notes

Reaction equation

HRID 976225 reaction equation
[Cl:1][C:2]1[C:7]([O:8][CH:9]2[CH2:13][CH2:12][CH2:11][CH2:10]2)=[CH:6][C:5]([N:14]2[C:18](=[NH:19])[C:17](=[C:20]([CH3:22])[CH3:21])[O:16][C:15]2=[O:23])=[C:4]([F:24])[CH:3]=1.Cl>C1(C)C=CC=CC=1>[ClH:1].[Cl:1][C:2]1[C:7]([O:8][CH:9]2[CH2:10][CH2:11][CH2:12][CH2:13]2)=[CH:6][C:5]([N:14]2[C:18](=[NH:19])[C:17](=[C:20]([CH3:22])[CH3:21])[O:16][C:15]2=[O:23])=[C:4]([F:24])[CH:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 15472215HCID 15472215, compound

Product 1

HCID 19966772HCID 19966772, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

The resulting 3-(4-chloro-5-cyclopentyloxy-2-fluorophenyl)-4-imino-5-isopropylideneoxazolidine-2-one was dissolved in toluene and conc. HCl (ca. 2 eq.) was added to the solution at room temperature; the mixture was stirred thoroughly and the resulting white solids was subjected to filtration, washed thoroughly with toluene and hexane and subsequently dried to yield 3-(4-chloro-5-cyclopentyloxy-2-fluorophenyl)-4-imino-5-isopropylideneoxazolidine-2-one hydrochloride (compound 1) almost quantitatively.

Workup

  1. filtrationthe resulting white solids was subjected to filtration
  2. washwashed thoroughly with toluene and hexane
  3. customsubsequently dried

Sources & evidence

ORD record
ord-613971b9a8744951b81d6124a3017d84
Source dataset
uspto-grants-1997_03
Patent number
US05612289

Reaction notes

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