Hydrochloric Acid → HCID 178501833, compound

HRID 976257Notes

Reaction equation

HRID 976257 reaction equation
[ClH:1].[NH2:2][C@H:3]1[CH2:8][CH2:7][C@H:6]([O:9][CH2:10][C:11]([O:13][C:14](C)(C)C)=[O:12])[CH2:5][CH2:4]1>CO>[ClH:1].[NH2:2][C@H:3]1[CH2:8][CH2:7][C@H:6]([O:9][CH2:10][C:11]([O:13][CH3:14])=[O:12])[CH2:5][CH2:4]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178451370HCID 178451370, compound

Product 1

HCID 178501833HCID 178501833, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Hydrochloric acid gas is piped for an hour over a solution of 59.4 g of tert.butyl (trans-4-aminocyclohexyl)oxyacetate in 500 ml of methanol, cooled in an ice bath, and then the mixture is stirred overnight at ambient temperature. It is evaporated to dryness, the residue is triturated with acetone and the solid is suction filtered and dried.

Workup

  1. temperaturecooled in an ice bath
  2. customIt is evaporated to dryness
  3. customthe residue is triturated with acetone
  4. filtrationfiltered
  5. customdried

Sources & evidence

ORD record
ord-78f9cc1f0fb44aff9dfe05c9f3b79710
Source dataset
uspto-grants-1997_03
Patent number
US05612335

Reaction notes

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