反应详情

100 mg (0.26 mmol) of N-[3-(1,1,2,2-tetrafluoro-ethoxy)-phenyl]-4-(N-oxido-4-pyridyl)-2-pyrimidineamine, 90 μl (0.72 mmol) or trimethylsiyl cyanide and 66 μl (0.72 mmol of N,N-dimethyl-carbamoyl chloride are dissolved in 5 ml of acetonitrile and stirred at 60° for 14 h. Concentration under reduced pressure and recrystalisation from tetrahydrofuran/diethyl ether give N-[3-(1,1,2,2-tetrafluoro-ethoxy)phenyl]-4-(2-cyano-4-pyridyl)-2-pyrimidineamine; FAB-MS: 390 (M+ +H), Rf =0.7 (hexane:ethyl acetate=1:1).

1. concentrationConcentration
2. customunder reduced pressure and recrystalisation from tetrahydrofuran/diethyl ether