Iodoethane → HCID 21468880, compound

HRID 976584Notes

Reaction equation

HRID 976584 reaction equation
[C:1]([C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]1[CH:10]=[C:11]2[C:15](=[CH:16][CH:17]=1)[NH:14][CH:13]=[CH:12]2)#[N:2].[CH2:18]([Mg]Br)[CH3:19].C(I)C>C1COCC1>[C:1]([C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]1[CH:10]=[C:11]2[C:15](=[CH:16][CH:17]=1)[NH:14][CH:13]=[C:12]2[CH2:18][CH3:19])#[N:2]

Participants

5

Reactant 3

HCID 6340IodoethaneHCID 21468934HCID 21468934, compoundHCID 178418443HCID 178418443, compound

Product 1

HCID 21468880HCID 21468880, compoundYield 31.6%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

5-(2-cyanophenyl) indole (1.26 mmoles, 630 mg) was dissolved in THF (20 ml) and treated with ethylmagnesium bromide (1.26 mmoles, 0.630ml) and ethyl iodide (3.45 mmoles, 0.54 g) as in Example 24 to yield 98 mg of 5-(2-cyanophenyl)-3-ethylindole. (MS)

Sources & evidence

ORD record
ord-a942bc7e57ee4295b4a81c197f93fe7a
Source dataset
uspto-grants-1997_03
Patent number
US05612360

Reaction notes

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