Tetrahydrofuran → tert-Butyl 4-[(6-bromopyridin-2-yl)(hydroxy)methyl]piperazine-1-carboxylate
Reaction equation
[Br:1][c:2]1[n:3][c:4]([Br:8])[cH:5][cH:6][cH:7]1.[CH2:9]([Li:10])[CH2:11][CH2:12][CH3:13].[CH:14](=[O:15])[N:16]1[CH2:17][CH2:18][N:19]([C:22](=[O:23])[O:24][C:25]([CH3:26])([CH3:27])[CH3:28])[CH2:20][CH2:21]1.[O:29]1[CH2:30][CH2:31][CH2:32][CH2:33]1>>[c:2]1([CH:14]([OH:15])[N:16]2[CH2:17][CH2:18][N:19]([C:22](=[O:23])[O:24][C:25]([CH3:26])([CH3:27])[CH3:28])[CH2:20][CH2:21]2)[n:3][c:4]([Br:8])[cH:5][cH:6][cH:7]1Participants
5
Sources & evidence
- ORD record
- ord-8edca57966b143999b9de747a2afa267
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (2/10)
Reaction notes
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