Methyl iodide → HCID 22145398, compound

HRID 977002Notes

Reaction equation

HRID 977002 reaction equation
[C:1]([C:4]1[CH:8]=[C:7]([CH3:9])[N:6]([CH2:10][CH2:11][OH:12])[N:5]=1)(=[O:3])[CH3:2].[CH3:13]I.[H-].[Na+]>COCCOC.[Ag]=O>[C:1]([C:4]1[CH:8]=[C:7]([CH3:9])[N:6]([CH2:10][CH2:11][O:12][CH3:13])[N:5]=1)(=[O:3])[CH3:2]

Participants

6

Reactant 3

HCID 6328Methyl iodideHCID 24758Sodium hydrideHCID 22145372HCID 22145372, compound

Product 1

HCID 22145398HCID 22145398, compoundYield 22%

Reagents, catalysts & solvents 2

HCID 92152Silver(II) oxideCatalystHCID 80711,2-DimethoxyethaneSolvent

Procedure

3-Acetyl-1-(2-hydroxyethyl)-5-methylpyrazole (0.63 g, 3.77 mM) in ethylene glycol dimethyl ether (10 ml) was treated with silver oxide (0.87 g, 3.77 mM) and methyl iodide (0.28 ml, 4.5mM). Sodium hydride (0.17 g 60% dispersion in oil, 4.14 mM) was added and the mixture stirred for 2 h, then filtered through celite and evaporated. Purification on silica gel eluting with ethyl acetate gave the title compound (0.157 g, 22%); νmax 1681 cm-1 ; δH (CDCl3) 2.32 (3H, s), 2.50 (3H, s), 3.30 (3H, s), 3.78 (2H, t, J5.4 Hz), 4.25 (2H, t, J5.4 Hz), and 6.51 (1H, s); EI m/e 182 (65%).

Workup

  1. filtrationfiltered through celite
  2. customevaporated
  3. customPurification on silica gel eluting with ethyl acetate

Sources & evidence

ORD record
ord-608bd885b2e9482c9f3356d0f15e63ee
Source dataset
uspto-grants-1997_03
Patent number
US05612477

Reaction notes

Loading…