Water → Ethyl 4-bromo-3-oxobutanoate

HRID 977044Notes

Reaction equation

HRID 977044 reaction equation
[C:1]([O:7][CH2:8][CH3:9])(=[O:6])[CH2:2][C:3]([CH3:5])=[O:4].[Br:10]Br.O>C(O)(=O)C>[Br:10][CH2:5][C:3](=[O:4])[CH2:2][C:1]([O:7][CH2:8][CH3:9])=[O:6]

Participants

5

Reactant 3

HCID 962WaterHCID 8868Ethyl AcetoacetateHCID 24408Bromine

Product 1

HCID 575284Ethyl 4-bromo-3-oxobutanoate

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

32.5 g (0.25 mol) of ethyl acetoacetate are dissolved in 64 ml of glacial acetic acid. 40 g (0.25 mol) of bromine are added dropwise to the cooled solution. The mixture is left to stand overnight and then poured into cold water. The oil obtained is washed with water, dried and distilled in a glass filter pump vacuum.

Workup

  1. waitThe mixture is left
  2. customThe oil obtained
  3. washis washed with water
  4. customdried
  5. distillationdistilled in a glass
  6. filtrationfilter pump vacuum

Sources & evidence

ORD record
ord-ab38a895a7fc49798a9135993320f5db
Source dataset
uspto-grants-1997_03
Patent number
US05614351

Reaction notes

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