Methyl iodide → HCID 19965111, compound

HRID 977096Notes

Reaction equation

HRID 977096 reaction equation
[OH:1][C:2]1[N:3]=[C:4]([C:12]2[CH:17]=[CH:16][C:15]([O:18][CH:19]([CH3:21])[CH3:20])=[CH:14][CH:13]=2)[S:5][C:6]=1[C:7]([O:9]CC)=[O:8].[H-].[Na+].[CH3:24]I>>[CH:19]([O:18][C:15]1[CH:16]=[CH:17][C:12]([C:4]2[S:5][C:6]([C:7]([OH:9])=[O:8])=[C:2]([O:1][CH3:24])[N:3]=2)=[CH:13][CH:14]=1)([CH3:21])[CH3:20]

Participants

4

Reactant 3

HCID 6328Methyl iodideHCID 24758Sodium hydrideHCID 135737463HCID 135737463, compound

Product 1

HCID 19965111HCID 19965111, compoundYield 72%

Procedure

Ethyl 4-hydroxy-2-(4-isopropoxyphenyl)-5-thiazolecarboxylate prepared in Example 22 was methylated with sodium hydride and methyl iodide and hydrolyzed by a conventional process to give 2-(4-isopropoxyphenyl)-4-methoxy-5-thiazolecarboxylic acid (yield: 72%).

Sources & evidence

ORD record
ord-c59bcd9498a24a479867e0a0db354d7b
Source dataset
uspto-grants-1997_03
Patent number
US05614520

Reaction notes

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