反应详情

A mixture of N-(1-ethylpyrazol-5-yl) -4-methoxyanthranilic acid (13.3 g, 0.051 mol) and POCl3 (125 ml) was refluxed for 3 hours, then was allowed to sit overnight. The volume of POCl3 was reduced, then ice/water, followed by NH4OH was added. A precipitate formed which was collected by filtration and dried in a vacuum oven at 50° C. to afford 11.51 g (87%) of 1-ethyl-4-chloro-7-methoxy-1H-pyrazolo[3,4-b]quinoline, m.p. 95°-98° C.

1. temperaturewas refluxed for 3 hours
2. additionwas added
3. customA precipitate formed which
4. filtrationwas collected by filtration
5. customdried in a vacuum oven at 50° C.