Dimethylamine → 7-(Dimethylamino)hept-5-ynylamine

HRID 977981Notes

Reaction equation

[CH2:1]([N:7]1[C:11](=O)[C:10]2=[CH:13][CH:14]=[CH:15][CH:16]=[C:9]2[C:8]1=O)CCCC#C.C=O.C[NH:21]C.O.NN>>[CH3:1][N:7]([CH3:11])[CH2:8][C:9]#[C:16][CH2:15][CH2:14][CH2:13][CH2:10][NH2:21]

Participants

Reactant 4

HCID 674Dimethylamine

HCID 712Formaldehyde

HCID 24654Hydrazine hydrate (1:1)

HCID 3346053N-(5-Hexynyl)phthalimide

Product 1

HCID 201476467-(Dimethylamino)hept-5-ynylamine

Procedure

In a manner similar to Description 1 (iii) and (iv) reaction of N-5-hexynylphthalimide, paraformaldehyde and dimethylamine, followed by treatment with hydrazine hydrate gave the title compound b.p. 110°-20° C. (0.3 mm Hg).

Sources & evidence

ORD record: ord-508f477bc9734dd6883f26d90d9dfd96
Source dataset: uspto-grants-1987_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04663331

Reaction notes

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