Hydrochloric Acid → SC 41661A

HRID 977999Notes

Reaction equation

HRID 977999 reaction equation
[CH3:1][C:2]([C:5]1[CH:6]=[C:7]([S:16][CH2:17][CH2:18][C:19]([N:21]([CH3:30])[CH2:22][CH2:23][C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][N:25]=2)=[O:20])[CH:8]=[C:9]([C:12]([CH3:15])([CH3:14])[CH3:13])[C:10]=1[OH:11])([CH3:4])[CH3:3].[ClH:31]>C(OCC)C.C(O)(C)C>[ClH:31].[CH3:15][C:12]([C:9]1[CH:8]=[C:7]([S:16][CH2:17][CH2:18][C:19]([N:21]([CH3:30])[CH2:22][CH2:23][C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][N:25]=2)=[O:20])[CH:6]=[C:5]([C:2]([CH3:1])([CH3:3])[CH3:4])[C:10]=1[OH:11])([CH3:13])[CH3:14]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 188931HCID 188931, compound

Product 1

HCID 188930SC 41661A

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 3776IsopropanolSolvent

Procedure

The title compound of Example 4, (2.0 g) was dissolved in ethyl ether (400 ml). With rapid stirring, a saturated solution of hydrogen chloride in isopropyl alcohol was added dropwise until no further precipitation occurred. The oily material was stirred for 20 hours. The ethyl ether was decanted and the residue crystallized from ethyl acetate/ethyl ether to give the title compound (700 mg), m.p. ca. 153°-156° C.

Workup

  1. customThe ethyl ether was decanted
  2. customthe residue crystallized from ethyl acetate/ethyl ether

Sources & evidence

ORD record
ord-c3677b888dfa41a2bfc45e11078b96ad
Source dataset
uspto-grants-1987_05
Patent number
US04663333

Reaction notes

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