2,6-Di-tert-butyl-4-mercaptophenol → 3-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]thio]-N-ethyl-N-(4-pyridinylmethyl)propanamide

HRID 978001Notes

Reaction equation

HRID 978001 reaction equation
[CH2:1]([N:3]([CH2:8][C:9]1[CH:14]=[CH:13][N:12]=[CH:11][CH:10]=1)[C:4](=[O:7])[CH:5]=[CH2:6])[CH3:2].[CH3:15][C:16]([C:19]1[CH:24]=[C:23]([SH:25])[CH:22]=[C:21]([C:26]([CH3:29])([CH3:28])[CH3:27])[C:20]=1[OH:30])([CH3:18])[CH3:17]>C(N(CC)CC)C>[CH3:29][C:26]([C:21]1[CH:22]=[C:23]([S:25][CH2:6][CH2:5][C:4]([N:3]([CH2:1][CH3:2])[CH2:8][C:9]2[CH:10]=[CH:11][N:12]=[CH:13][CH:14]=2)=[O:7])[CH:24]=[C:19]([C:16]([CH3:18])([CH3:17])[CH3:15])[C:20]=1[OH:30])([CH3:27])[CH3:28]

Participants

4

Reactant 2

HCID 703702,6-Di-tert-butyl-4-mercaptophenolHCID 19826117HCID 19826117, compound

Product 1

HCID 138229403-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]thio]-N-ethyl-N-(4-pyridinylmethyl)propanamide

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

The title compound was prepared according to the method of Example 4 from N-ethyl-N-(4-pyridinylmethyl)-2-propenamide (1.5 g, 0.00788 mole,), 2,6-bis(1,1-dimethyl-ethyl)-4-mercaptophenol (2.06 g, 0.00867 mole,) and triethylamine (1 ml) to provide 3.0 g of product, m.p. ca. 121°-123° C.

Sources & evidence

ORD record
ord-19080efa9db246d594b87d4ee6166208
Source dataset
uspto-grants-1987_05
Patent number
US04663333

Reaction notes

Loading…