反应详情

A solution of methyl 2-(p-methoxybenzylthio)-5-trifluoromethylbenzoate (1.0 g, 2.8 mmol) and anisole (335 μl) in trifluoroacetic acid (10 ml) was stirred at reflux temperature for 20 minutes under a nitrogen atmosphere. The mixture was evaporated under diminished pressure and co-evaporated several times with toluene. The mercaptan was used without further purification in the subsequent step below. NMR (CDCl3, 60 MHz): δ3.88 (s, CO2CH3) p.p.m.

1. temperatureat reflux temperature for 20 minutes under a nitrogen atmosphere
2. customThe mixture was evaporated under diminished pressure and co-evaporated several times with toluene
3. customThe mercaptan was used without further purification in the subsequent step below