Hydrochloric Acid → HCID 13849492, compound

HRID 978111Notes

Reaction equation

HRID 978111 reaction equation
C([O:4][C:5]1[C:10]2[C:11]([CH3:25])=[C:12]([C:14]([O:16][CH2:17][C:18]3[CH:23]=[CH:22][C:21]([Cl:24])=[CH:20][CH:19]=3)=[O:15])[O:13][C:9]=2[CH:8]=[CH:7][CH:6]=1)(=O)C.Cl>CO.C([O-])([O-])=O.[K+].[K+].O>[OH:4][C:5]1[C:10]2[C:11]([CH3:25])=[C:12]([C:14]([O:16][CH2:17][C:18]3[CH:19]=[CH:20][C:21]([Cl:24])=[CH:22][CH:23]=3)=[O:15])[O:13][C:9]=2[CH:8]=[CH:7][CH:6]=1

Participants

6

Reactant 2

HCID 313Hydrochloric AcidHCID 13849490HCID 13849490, compound

Product 1

HCID 13849492HCID 13849492, compoundYield 96%

Reagents, catalysts & solvents 3

HCID 11430Potassium CarbonateCatalystHCID 887MethanolSolventHCID 962WaterSolvent

Procedure

To the compound of Example 124 (0.2 g, 0.55 mmoles) dissolved in MeOH (10 ml) was added 2-3 drops K2CO3 10% w/v in H2O and the reaction mixture was stirred at 25° overnight. HCl (0.1N, 20 ml) was added and the mixture was filtered. The solid was air dried to give 0.170 g or 96% of the title compound, m.p. 202°-204° C.

Workup

  1. filtrationthe mixture was filtered
  2. customdried

Sources & evidence

ORD record
ord-e35e949f3bf648e59184819b2919a362
Source dataset
uspto-grants-1987_05
Patent number
US04663347

Reaction notes

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