反应详情

温度

50 °C

In a 500 ml flask, was placed 16.84 gm of 6-ethyl isatin which was covered with 216 ml of 1.5M sodium hydroxide solution. With stirring, the mixture was warmed to 50° C. Heating was discontinued and the solution was treated with a 30% solution of hydrogen peroxide (24 ml) which was added at such a rate to maintain the temperature at between 50° to 65° C. The mixture was left to slowly cool to room temperature and was then acidified to pH 4 with concentrated hydrochloric acid. The precipitated product was then collected by filtration: mp. 117°-120° C.; yield 8.93 gm.

1. customIn a 500 ml flask, was placed
2. temperatureHeating
3. additionwas added at such a rate
4. temperatureto maintain the temperature at between 50° to 65° C
5. waitThe mixture was left
6. temperatureto slowly cool to room temperature
7. filtrationThe precipitated product was then collected by filtration