Methylamine → Methyl 2-methyl-3-(methylamino)propanoate

HRID 978431Notes

Reaction equation

HRID 978431 reaction equation
[CH3:1][NH2:2].[CH3:3][C:4](=[CH2:9])[C:5]([O:7][CH3:8])=[O:6]>CO>[CH3:9][CH:4]([CH2:3][NH:2][CH3:1])[C:5]([O:7][CH3:8])=[O:6]

Participants

4

Reactant 2

HCID 6329MethylamineHCID 6658Methyl Methacrylate

Product 1

HCID 13129055Methyl 2-methyl-3-(methylamino)propanoate

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

To a solution of 12.4 g of methylamine in 45 ml of methanol was added with stirring and ice-water cooling a solution of 60.2 g of methyl 2-methylacrylate in 40 ml of methanol over a period of 1 hour. The mixture was allowed to stand at room temperature for 3 days, was evaporated and the residue was distilled at aspirator pressure to give the methyl 2-methyl-3-methylaminopropionate, bp. 57°-59° C./15 mm Hg.

Workup

  1. customwas evaporated
  2. distillationthe residue was distilled at aspirator pressure

Sources & evidence

ORD record
ord-98473ee198ed4593b3a38c487823ae4c
Source dataset
uspto-grants-1987_05
Patent number
US04665087

Reaction notes

Loading…