Dihydrofolic Acid → Tetrahydrofolic acid

HRID 978629Notes

Reaction equation

HRID 978629 reaction equation
[C:1]([OH:32])(=[O:31])[CH2:2][CH2:3][C@H:4]([NH:8][C:9]([C:11]1[CH:30]=[CH:29][C:14]([NH:15][CH2:16][C:17]2[CH2:18][NH:19][C:20]3[N:21]=[C:22]([NH:24][C:25]([C:27]=3[N:28]=2)=[O:26])[NH2:23])=[CH:13][CH:12]=1)=[O:10])[C:5]([OH:7])=[O:6]>[Pt]>[C:1]([OH:32])(=[O:31])[CH2:2][CH2:3][C@H:4]([NH:8][C:9]([C:11]1[CH:12]=[CH:13][C:14]([NH:15][CH2:16][CH:17]2[NH:28][C:27]3[C:25](=[O:26])[NH:24][C:22]([NH2:23])=[N:21][C:20]=3[NH:19][CH2:18]2)=[CH:29][CH:30]=1)=[O:10])[C:5]([OH:7])=[O:6]

Participants

3

Reactant 1

HCID 135398604Dihydrofolic Acid

Product 1

HCID 135444742Tetrahydrofolic acidYield 65.7%

Reagents, catalysts & solvents 1

HCID 23939PlatinumCatalyst

Procedure

Then, 0.112 g of a 5% platinum-activated carbon catalyst (containing the noble metal in an amount of 0.26% by weight based on the dihydrofolic acid) was added to the flask, and hydrogenation was carried out in the same manner as described in Example 1 to obtain 1.439 g (65.7% yield) of tetrahydrofolic acid.

Workup

  1. additionwas added to the flask, and hydrogenation

Sources & evidence

ORD record
ord-fd143b4ce6a147c3b8afe18b0fe0c202
Source dataset
uspto-grants-1987_05
Patent number
US04665176

Reaction notes

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