Water → 2-[(2,4-Dimethylthiophen-3-yl)amino]-2-oxoethyl acetate

HRID 978925Notes

Reaction equation

HRID 978925 reaction equation
[CH3:1][C:2]1[S:3][CH:4]=[C:5]([CH3:8])[C:6]=1[NH2:7].C([O-])([O-])=O.[K+].[K+].O.[C:16]([O:19][CH2:20][C:21](Cl)=[O:22])(=[O:18])[CH3:17]>C(Cl)Cl>[CH3:1][C:2]1[S:3][CH:4]=[C:5]([CH3:8])[C:6]=1[NH:7][C:21](=[O:22])[CH2:20][O:19][C:16](=[O:18])[CH3:17]

Participants

6

Reactant 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 26297Acetoxyacetyl chlorideHCID 133411982,4-Dimethylthiophen-3-amine

Product 1

HCID 202010872-[(2,4-Dimethylthiophen-3-yl)amino]-2-oxoethyl acetate

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To 12.7 g (0.1 mol) of 2,4-dimethyl-3-aminothiophene, 13.8 g (0.1 mol) of K2CO3, 20 ml of water and 150 ml of methylene chloride are added dropwise at ambient temperature 15 g (0.11 mol) of acetoxyacetyl chloride.

Sources & evidence

ORD record
ord-da3227bced5c4028b9f8fb31f17761ae
Source dataset
uspto-grants-1987_05
Patent number
US04666502

Reaction notes

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