Water → HCID 20201113, compound

HRID 978929Notes

Reaction equation

HRID 978929 reaction equation
[CH3:1][C:2]1[C:6]([NH2:7])=[C:5]([CH3:8])[S:4][C:3]=1[C:9]([O:11][CH3:12])=[O:10].C([O-])([O-])=O.[K+].[K+].O.[Cl:20][CH2:21][C:22](Cl)=[O:23]>C(Cl)Cl>[C:9]([C:3]1[S:4][C:5]([CH3:8])=[C:6]([NH:7][C:22](=[O:23])[CH2:21][Cl:20])[C:2]=1[CH3:1])([O:11][CH3:12])=[O:10]

Participants

6

Reactant 4

HCID 962WaterHCID 6577Chloroacetyl chlorideHCID 11430Potassium CarbonateHCID 20201086HCID 20201086, compound

Product 1

HCID 20201113HCID 20201113, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To 12.25 g (0.066 mol) of methyl 3,5-dimethyl-4-aminothiophene-2-carboxylate, 9.1 g (0.066 mol) of K2CO3, 25 ml of water and 150 ml of methylene chloride are added without cooling 7.5 g (0.066 mol) of chloroacetyl chloride.

Sources & evidence

ORD record
ord-c555b0af5c9e462a925970d878737fde
Source dataset
uspto-grants-1987_05
Patent number
US04666502

Reaction notes

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