1H-Pyrazole-4-carboxylic acid, 5-(aminocarbonyl)-1-(3-chlorophenyl)- → HCID 178449045, compound

HRID 978950Notes

Reaction equation

HRID 978950 reaction equation
[C:1]([C:4]1[CH:5]=[N:6][N:7]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([Cl:18])[CH:13]=2)[C:8]=1[C:9]([NH2:11])=[O:10])([OH:3])=[O:2].[OH-].[CH2:20]([N+:24]([CH2:33][CH2:34][CH2:35][CH3:36])([CH2:29][CH2:30][CH2:31][CH3:32])[CH2:25][CH2:26][CH2:27][CH3:28])[CH2:21][CH2:22][CH3:23]>CO>[CH2:33]([N+:24]([CH2:20][CH2:21][CH2:22][CH3:23])([CH2:25][CH2:26][CH2:27][CH3:28])[CH2:29][CH2:30][CH2:31][CH3:32])[CH2:34][CH2:35][CH3:36].[C:1]([C:4]1[CH:5]=[N:6][N:7]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([Cl:18])[CH:13]=2)[C:8]=1[C:9]([NH-:11])=[O:10])([OH:3])=[O:2]

Participants

4

Reactant 2

HCID 1637151H-Pyrazole-4-carboxylic acid, 5-(aminocarbonyl)-1-(3-chlorophenyl)-HCID 2723671Tetrabutylammonium Hydroxide

Product 1

HCID 178449045HCID 178449045, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A 3.26 g. portion of 4-carboxy-1-(3-chlorophenyl)-5-pyrazolecarboxamide was slurried in 50 ml. of methanol and 12 ml. of 1M tetrabutyl ammonium hydroxide solution was added. The mixture was stirred for 30 minutes, and evaporated to dryness under vacuum to obtain 5.2 g. of product, m.p. 120°-121°. The product was identified by elemental analysis.

Workup

  1. customevaporated to dryness under vacuum
  2. customto obtain 5.2 g

Sources & evidence

ORD record
ord-ed5095fedc5b46a4890db1f85ce5e7d9
Source dataset
uspto-grants-1987_05
Patent number
US04666504

Reaction notes

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