Diethyl Ether → HCID 13576363, compound

HRID 979033Notes

Reaction equation

HRID 979033 reaction equation
[N:1]1([CH2:6][CH2:7][O:8][C:9]2[CH:14]=[CH:13][C:12]([CH:15]3OC(=O)[C:17](=[C:21]=[O:22])[CH2:16]3)=[CH:11][CH:10]=2)[CH:5]=[CH:4][N:3]=[CH:2]1.O.[NH2:24][NH2:25].CC[O:28][CH2:29]C>C(O)C>[OH:28][CH2:29][CH:16]1[C:15]([C:12]2[CH:11]=[CH:10][C:9]([O:8][CH2:7][CH2:6][N:1]3[CH:5]=[CH:4][N:3]=[CH:2]3)=[CH:14][CH:13]=2)=[N:25][NH:24][C:21](=[O:22])[CH2:17]1

Participants

5

Reactant 3

HCID 3283Diethyl EtherHCID 24654Hydrazine hydrate (1:1)HCID 86741514HCID 86741514, compound

Product 1

HCID 13576363HCID 13576363, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

5.2 g (0.017 mol) of 4-(4-(2-(1-imidazolyl)-ethoxy)phenyl)-carbonyl-γ-butyrolactone and 1 ml (0.02 mol) of hydrazine hydrate are stirred in 30 ml of ethanol at room temperature for 1 hour and then at 60° C. for 16 hours. After the mixture has been cooled, 15 ml of ether are added and the precipitated product is filtered off with suction, washed with either and dried.

Workup

  1. temperatureAfter the mixture has been cooled
  2. filtrationthe precipitated product is filtered off with suction
  3. washwashed with either and
  4. customdried

Sources & evidence

ORD record
ord-0f33313bb9e24d2b94bed1c817de75d5
Source dataset
uspto-grants-1987_05
Patent number
US04666902

Reaction notes

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