Acetic Acid → HCID 13576369, compound

HRID 979038Notes

Reaction equation

HRID 979038 reaction equation
[CH3:1][S:2][C:3]1[CH:8]=[CH:7][C:6]([CH:9]2OC(=O)[C:11](=[C:15]=[O:16])[CH2:10]2)=[CH:5][CH:4]=1.O.[NH2:18][NH2:19].[C:20]([OH:23])(=O)C>C(O)C>[CH3:1][S:2][C:3]1[CH:4]=[CH:5][C:6]([C:9]2[CH:10]([CH2:20][OH:23])[CH2:11][C:15](=[O:16])[NH:18][N:19]=2)=[CH:7][CH:8]=1

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 24654Hydrazine hydrate (1:1)HCID 86741516HCID 86741516, compound

Product 1

HCID 13576369HCID 13576369, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

10.6 g (0.045 mol) of 4-(4-methylmercaptophenyl)-carbonyl-γ-butyrolactone are stirred in 70 ml of ethanol with 2.5 g (0.05 mol) of hydrazine hydrate at room temperature for 90 minutes. After addition of 8 ml of acetic acid, the mixture is heated under reflux for 1 hour and cooled and the precipitate is filtered off with suction and dried.

Workup

  1. temperaturethe mixture is heated
  2. temperatureunder reflux for 1 hour
  3. temperaturecooled
  4. filtrationthe precipitate is filtered off with suction
  5. customdried

Sources & evidence

ORD record
ord-0731e8e6ecad40ad99af0a23006cf2f6
Source dataset
uspto-grants-1987_05
Patent number
US04666902

Reaction notes

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