Water → HCID 13491961, compound

HRID 979072Notes

Reaction equation

HRID 979072 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][C:15]2[CH:20]=[CH:19][C:18]([OH:21])=[C:17]([NH2:22])[CH:16]=2)[CH:5]=[CH:6][C:7]=1[OH:8].C(=O)(O)[O-].[Na+].O.Cl[CH2:30][C:31](Cl)=[O:32].[CH3:34][C:35](CC(C)C)=[O:36]>>[O:8]1[C:7]2[CH:6]=[CH:5][C:4]([CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][C:15]3[CH:20]=[CH:19][C:18]4[O:21][CH2:34][C:35](=[O:36])[NH:22][C:17]=4[CH:16]=3)=[CH:3][C:2]=2[NH:1][C:31](=[O:32])[CH2:30]1

Participants

6

Reactant 5

HCID 962WaterHCID 6577Chloroacetyl chlorideHCID 7909Methyl Isobutyl KetoneHCID 516892Sodium BicarbonateHCID 13910808HCID 13910808, compound

Product 1

HCID 13491961HCID 13491961, compound

Procedure

To a suspension of 2.1 g (0.007 mol) of 1,6-bis(3-amino-4-hydroxyphenyl)hexane in 10 ml of isobutyl methyl ketone was added 3.0 g (0.0357 mole) of sodium bicarbonate and 10 ml of water. The suspension was stirred in an ice bath and 1.9 g (0.016 mole) of chloroacetyl chloride was added dropwise. The reaction was carried out in a manner similar to that in Example 23 to yield 1.0 g of product of m.p. 219°-225° C.

Sources & evidence

ORD record
ord-59842010e7744dbabb249b02d821a506
Source dataset
uspto-grants-1987_05
Patent number
US04666909

Reaction notes

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