Hydrogen Peroxide → 4-chloro-3-methoxy-10-methyl-5-oxo-10H-phenothiazine
Reaction equation
[Cl:1][C:2]1[C:15]2[S:14][C:13]3[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=3)[N:7]([CH3:16])[C:6]=2[CH:5]=[CH:4][C:3]=1[O:17][CH3:18].[OH:19]O>C(O)(=O)C>[Cl:1][C:2]1[C:15]2[S:14](=[O:19])[C:13]3[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=3)[N:7]([CH3:16])[C:6]=2[CH:5]=[CH:4][C:3]=1[O:17][CH3:18]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 50 °C
Procedure
To 4-chloro-3-methoxy-10-methyl-10H-phenothiazine (0.5 g) (see Example 5) was added acetic acid (12 ml) and hydrogen peroxide (2 ml). The reaction mixture was heated at 50° C. for 15 minutes and then, evaporated to dryness. The corresponding sulfoxide (0.5 g) (4-chloro-3-methoxy-10-methyl-5-oxo-10H-phenothiazine) was obtained by crystallization (m.p. decomposed at 141° C.).
Workup
- customevaporated to dryness
Sources & evidence
- ORD record
- ord-f54d01d90ec04bcfa984328e5404f99b
- Source dataset
- uspto-grants-1987_05
- Patent number
- US04666907
Reaction notes
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