3-Nitrobenzenesulfonic acid → HCID 13370240, compound

HRID 979285Notes

Reaction equation

HRID 979285 reaction equation
[N:1]1([CH2:6][C:7]2[S:11][C:10]([C:12]3[CH2:13][CH2:14][C:15](=[O:18])[NH:16][N:17]=3)=[CH:9][CH:8]=2)[CH:5]=[CH:4][CH:3]=[N:2]1.[Na].[N+](C1C=C(S(O)(=O)=O)C=CC=1)([O-])=O.[OH-].[Na+]>O.C(O)(=O)C>[N:1]1([CH2:6][C:7]2[S:11][C:10]([C:12]3[CH:13]=[CH:14][C:15](=[O:18])[NH:16][N:17]=3)=[CH:9][CH:8]=2)[CH:5]=[CH:4][CH:3]=[N:2]1

Participants

7

Reactant 4

HCID 73873-Nitrobenzenesulfonic acidHCID 14798Sodium HydroxideHCID 5360545SodiumHCID 13370245HCID 13370245, compound

Product 1

HCID 13370240HCID 13370240, compound

Reagents, catalysts & solvents 2

HCID 176Acetic AcidSolventHCID 962WaterSolvent

Procedure

Analoguous to Example 4, the reaction is carried out with 20 g of 4.5-dihydro-6-[5-(pyrazol-1-yl-methyl)-thien-2-yl]-3(2H)-pyridazinone (Example 3), 19.2 g of the sodium salt of 3-nitrobenzenesulfonic acid and 13.5 g of sodium hydroxide in 200 ml of water. The reaction mixture is neutralized by the addition of 16 ml of acetic acid.

Sources & evidence

ORD record
ord-628f1de46ff44501a6b4924bb22a662c
Source dataset
uspto-grants-1987_05
Patent number
US04667033

Reaction notes

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