Hydrochloric Acid → 2-Amino-5-methoxybenzene-1-thiol

HRID 979295Notes

Reaction equation

HRID 979295 reaction equation
[OH-].[K+].NC1[S:5][C:6]2[CH:12]=[C:11]([O:13][CH3:14])[CH:10]=[CH:9][C:7]=2[N:8]=1.Cl>C(O)(=O)C>[NH2:8][C:7]1[CH:9]=[CH:10][C:11]([O:13][CH3:14])=[CH:12][C:6]=1[SH:5]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 156302-Amino-6-methoxybenzothiazole

Product 1

HCID 2355092-Amino-5-methoxybenzene-1-thiol

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

To a solution of potassium hydroxide 8N (1.3 l) was added 2-amino-6-methoxybenzothiazole (750 g) and the mixture was refluxed for 18 hours. The resulting solution was neutralized by the addition of concentrated HCl, to pH 8.0, then acetic acid to pH 6.0. The precipitate which formed was filtered and washed with water to afford the title compound which was used immediately in Step 3.

Workup

  1. temperaturethe mixture was refluxed for 18 hours
  2. customThe precipitate which formed
  3. filtrationwas filtered
  4. washwashed with water

Sources & evidence

ORD record
ord-3af2568caab6451eb30bf452ef4f9beb
Source dataset
uspto-grants-1987_05
Patent number
US04667032

Reaction notes

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