Potassium Carbonate → HCID 129140, compound

HRID 979459Notes

Reaction equation

HRID 979459 reaction equation
[Cl:1][C:2]1[C:12]2[N:11]([C:13](=[O:22])[CH2:14][CH:15]3[CH2:20][CH2:19][N:18]([CH3:21])[CH2:17][CH2:16]3)[C:10]3[CH:23]=[CH:24][CH:25]=[CH:26][C:9]=3[C:8](=[O:27])[NH:7][C:6]=2[CH:5]=[CH:4][CH:3]=1.C([C@@H]([C@H](C([O-])=O)O)O)([O-])=O.C([O-])([O-])=O.[K+].[K+]>O>[Cl:1][C:2]1[C:12]2[N:11]([C:13](=[O:22])[CH2:14][CH:15]3[CH2:20][CH2:19][N:18]([CH3:21])[CH2:17][CH2:16]3)[C:10]3[CH:23]=[CH:24][CH:25]=[CH:26][C:9]=3[C:8](=[O:27])[NH:7][C:6]=2[CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 86741541HCID 86741541, compound

Product 1

HCID 129140HCID 129140, compoundYield 108.1%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

5 g of (+)-6-Chloro-5,10-dihydro-5-[(1-methyl-4-piperidinyl)-acetyl] -11H-dibenzo[b,e][1,4]diazepin-11-one-L-(+)-tart rate were dissolved in water, mixed with potash and extracted with methylene chloride. The extracts were combined and evaporated off several times with ethanol. 3.9 g (95% of theory) of (+)-6-chloro-5,10-dihydro-5-[(1-methyl-4-piperidinyl)-acetyl]-11H-dibenzo[b,e][1,4]diazepin-11-one were obtained.

Workup

  1. extractionextracted with methylene chloride
  2. customevaporated off several times with ethanol

Sources & evidence

ORD record
ord-5ef814044a9e4b73b02d6fbdad4ca47c
Source dataset
uspto-grants-1987_05
Patent number
US04668674

Reaction notes

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