HCID 86741188, compound → HCID 20223040, compound

HRID 979820Notes

Reaction equation

HRID 979820 reaction equation
[NH:1]1[CH2:5][CH2:4][N:3]=[C:2]1[CH:6]1[C:11]2=[CH:12][CH:13]=[C:14]3[C:18]([N:17](C(OCC)=O)[CH2:16][CH2:15]3)=[C:10]2[CH2:9][CH2:8][CH2:7]1>Cl>[NH:3]1[CH2:4][CH2:5][N:1]=[C:2]1[CH:6]1[C:11]2=[CH:12][CH:13]=[C:14]3[C:18]([NH:17][CH2:16][CH2:15]3)=[C:10]2[CH2:9][CH2:8][CH2:7]1

Participants

3

Reactant 1

HCID 86741188HCID 86741188, compound

Product 1

HCID 20223040HCID 20223040, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Conditions

Temperature
0 °C

Procedure

A solution of the product from Example 119 (0.38 g) in 6N hydrochloric acid (40 ml) was refluxed for 14 hours. The reaction mixture was cooled to 0° C., basified to pH 11 and extracted with methylene chloride. The organic layer was separated, dried and evaporated to afford the desired compound.

Workup

  1. extractionextracted with methylene chloride
  2. customThe organic layer was separated
  3. customdried
  4. customevaporated

Sources & evidence

ORD record
ord-a4b88f7d27eb410f959ab6277836bc83
Source dataset
uspto-grants-1987_01
Patent number
US04634705

Reaction notes

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